Flow control in our vessels: vascular valves make sure there is no way back.
Aug 2012
Source
Lymphatic Development Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London, WC2A 3LY, UK, e.bazigou@imperial.ac.uk.
Abstract
The efficient transport of blood and lymph relies on competent intraluminal valves that ensure unidirectional fluid flow through the vessels. In the lymphatic vessels, lack of luminal valves causes reflux of lymph and can lead to lymphedema, while dysfunction of venous valves is associated with venous hypertension, varicose veins, and thrombosis that can lead to edema and ulcerations. Despite their clinical importance, the mechanisms that regulate valve formation are poorly understood and have only recently begun to be characterized. Here, we discuss new findings regarding the development of venous and lymphatic valves that indicate the involvement of common molecular mechanisms in regulating valve formation in different vascular beds.
Full Text Article available through Springerlink. URL will not work when placed in this article.
http://www.springerlink.com/content/k784vh15p7040q7n/
http://www.springerlink.com/content/k784vh15p7040q7n/
